ketu po sjell nje abstract mbi nje artikull te publikuar tani ne Maj ne Journal of Thoracic and Cardiovascular Surgery (artikulli i plote ishte me leke).gjithsesi ky shkrim vlereson me shume efektet ne distance 5 vjetesh te nje operacioni te kryer ne hipotermi mbi trurin.
Neuroprotective Effect of Mild Hypothermia in Patients Undergoing Coronary Artery Surgery With Cardiopulmonary Bypass: Five-Year Follow-up of a Randomized Trial
(J Thorac Cardiovasc Surg. 2007 May;133(5):1206-11)
Objective: In a randomized trial of 223 patients undergoing coronary artery surgery with cardiopulmonary bypass, we have reported a neuroprotective effect of mild hypothermia. To determine whether the beneficial effect of mild hypothermia was long-lasting, we repeated the psychometric tests in 131 patients after 5 years.
Methods: Patients were cooled to 32 degrees C during aortic crossclamping and then randomized to rewarming to either 34 degrees C or 37 degrees C, with no further rewarming until arrival in intensive care unit. Cognitive function was measured preoperatively and 1 week and 5 years postoperatively with a battery of 11 psychometric tests interrogating verbal memory, attention, and psychomotor speed and dexterity.
Results: Patients who had greater cognitive decline 1 week after surgery showed poorer performance 5 years later. The magnitude of cognitive decline over 5 years was modest. The incidence of deficits defined as a 1 standard deviation [SD] decline in at least 1 of 3 factors was not different between temperature groups. Fewer patients in the hypothermic group had deficits that persisted over the 5 years, but this difference did not attain statistical significance (RR = 0.64, P = .16).
Conclusions: The effect of surgery on cognitive function observed early after surgery is an important predictor of cognitive performance 5 years later. Although there was evidence of a neuroprotective effect of mild hypothermia early after surgery in the original cohort, the results after 5 years were inconclusive. In general, the magnitude of cognitive changes over 5 years was modest. We believe that further trials investigating the efficacy of mild hypothermia in patients having cardiac surgery are warranted.
do kishte qene interesante te gjehej artikulli i plote per faktin se mund te kontrolloheshin edhe referencat sepse me shume mundesi ka edhe shkrime te tjera qe do kene te bejne me temen...gjithsesi...
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