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- Mjekësia (http://www.forumihorizont.com/forumdisplay.php3?forumid=266)
-- medical sciences (shkencat mjeksore) (http://www.forumihorizont.com/showthread.php3?threadid=8624)

his brain VS her brain (part 9)

Certain brain abnormalities underlying schizophrenia appear to differ in men and women as well. Ruben Gur, Raquel Gur and their colleagues at the University of Pennsylvania have spent years investigating sex-related differences in brain anatomy and function. In one project, they measured the size of the orbitofrontal cortex, a region involved in regulating emotions, and compared it with the size of the amygdala, implicated more in producing emotional reactions. The investigators found that women possess a significantly larger orbitofrontal-to-amygdala ratio (OAR) than men do. One can speculate from these findings that women might on average prove more capable of controlling their emotional reactions.
In additional experiments, the researchers discovered that this balance appears to be altered in schizophrenia, though not identically for men and women. Women with schizophrenia have a decreased OAR relative to their healthy peers, as might be expected. But men, oddly, have an increased OAR relative to healthy men. These findings remain puzzling, but, at the least, they imply that schizophrenia is a somewhat different disease in men and women and that treatment of the disorder might need to be tailored to the sex of the patient.

Sex Matters
in a comprehensive 2001 report on sex differences in human health, the prestigious National Academy of Sciences asserted that "sex matters. Sex, that is, being male or female, is an important basic human variable that should be considered when designing and analyzing studies in all areas and at all levels of biomedical and health-related research."

Neuroscientists are still far from putting all the pieces together--identifying all the sex-related variations in the brain and pinpointing their influences on cognition and propensity for brain-related disorders. Nevertheless, the research conducted to date certainly demonstrates that differences extend far beyond the hypothalamus a nd mating behavior. Researchers and clinicians are not always clear on the best way to go forward in deciphering the full influences of sex on the brain, behavior and responses to medications. But growing numbers now agree that going back to assuming we can evaluate one sex and learn equally about both is no longer an option.

and thats all of the article...it was a bit long but i think it worth the effort...i have to read it all from the beginning myself becouse when i first read it,it was in italian in the "le scienze" magazine...the results are very interesting and complicate the life of the researchers but at the same time open new ways to understand our body better...